Survival analysis is the branch of statistics that studies the relation between the characteristics of living entities and their respective survival times, taking into account the partial information held by censored cases. A good analysis can, for example, determine whether one medical treatment for a group of patients is better than another. With the rise of machine learning, survival analysis can be modeled as learning a function that maps studied patients to their survival times. To succeed with that, there are three crucial issues to be tackled. First, some patient data is censored: we do not know the true survival times for all patients. Second, data is scarce, which led past research to treat different illness types as domains in a multi-task setup. Third, there is the need for adaptation to new or extremely rare illness types, where little or no labels are available. In contrast to previous multi-task setups, we want to investigate how to efficiently adapt to a new survival target domain from multiple survival source domains. For this, we introduce a new survival metric and the corresponding discrepancy measure between survival distributions. These allow us to define domain adaptation for survival analysis while incorporating censored data, which would otherwise have to be dropped. Our experiments on two cancer data sets reveal a superb performance on target domains, a better treatment recommendation, and a weight matrix with a plausible explanation.

通过以人为本的研究（HCR），我们可以引导研究活动，以便研究结果对人类利益相关者（例如最终用户）有益。但是，是什么使研究以人为中心为中心？我们通过提供工作定义来解决这个问题，并定义如何将研究管道分为不同的阶段，在这些阶段中可以添加以人为中心的组件。此外，我们使用HCR组件讨论了现有的NLP，并定义了一系列的指导问题，这些问题可以作为有兴趣探索以人为中心的研究方法的研究人员的起点。我们希望这项工作能够激发研究人员完善所提出的定义，并提出其他对实现HCR有意义的问题。

随着现实应用程序中AI系统的兴起，需要可靠和值得信赖的AI。一个基本方面是可解释的AI系统。但是，关于应如何评估可解释的AI系统的商定标准。受图灵测试的启发，我们引入了一个以人为本的评估框架，领先的领域专家接受或拒绝AI系统和另一个领域专家的解决方案。通过比较提供的解决方案的接受率，我们可以评估AI系统与域专家相比的性能，以及AI系统的解释（如果提供）是否可以理解。该设置与图灵测试相当 - 可以作为各种以人为中心的AI系统评估的框架。我们通过提出两个实例来证明这一点：（1）评估系统的分类准确性，可以选择合并标签不确定性； （2）评估以人为中心确定提供的解释的有用性。

特征表示的相似性在与域适应有关的问题的成功中起着枢转作用。特征相似性包括边际分布的不变性以及给定所需响应$ Y $（例如，类标签）的条件分布的闭合性。不幸的是，传统方法始终学习此类功能，而无需完全考虑到$ Y $以$ y $以$ y $考虑到信息，这又可能导致条件分布的不匹配或歧视结构的歧视结构的混合。在这项工作中，我们介绍了最近提出的冯Neumann有条件分歧，以提高多个域的可转移。我们表明，这种新的分歧是可差异的，并且有资格容易地量化功能与$ y $之间的功能依赖性。给定多个源任务时，我们将这种分歧整合到捕获$ y $，并且设计新颖的学习目标，假设这些源任务同时或顺序观察。在这两种情况下，我们在新任务的较小概括误差方面获得了对最先进的方法的有利性能，以及在源任务上丢失的灾难性遗忘的较少（在顺序设置中）。

Unsupervised object discovery aims to localize objects in images, while removing the dependence on annotations required by most deep learning-based methods. To address this problem, we propose a fully unsupervised, bottom-up approach, for multiple objects discovery. The proposed approach is a two-stage framework. First, instances of object parts are segmented by using the intra-image similarity between self-supervised local features. The second step merges and filters the object parts to form complete object instances. The latter is performed by two CNN models that capture semantic information on objects from the entire dataset. We demonstrate that the pseudo-labels generated by our method provide a better precision-recall trade-off than existing single and multiple objects discovery methods. In particular, we provide state-of-the-art results for both unsupervised class-agnostic object detection and unsupervised image segmentation.

Adequate strategizing of agents behaviors is essential to solving cooperative MARL problems. One intuitively beneficial yet uncommon method in this domain is predicting agents future behaviors and planning accordingly. Leveraging this point, we propose a two-level hierarchical architecture that combines a novel information-theoretic objective with a trajectory prediction model to learn a strategy. To this end, we introduce a latent policy that learns two types of latent strategies: individual $z_A$, and relational $z_R$ using a modified Graph Attention Network module to extract interaction features. We encourage each agent to behave according to the strategy by conditioning its local $Q$ functions on $z_A$, and we further equip agents with a shared $Q$ function that conditions on $z_R$. Additionally, we introduce two regularizers to allow predicted trajectories to be accurate and rewarding. Empirical results on Google Research Football (GRF) and StarCraft (SC) II micromanagement tasks show that our method establishes a new state of the art being, to the best of our knowledge, the first MARL algorithm to solve all super hard SC II scenarios as well as the GRF full game with a win rate higher than $95\%$, thus outperforming all existing methods. Videos and brief overview of the methods and results are available at: https://sites.google.com/view/hier-strats-marl/home.

Owing to the success of transformer models, recent works study their applicability in 3D medical segmentation tasks. Within the transformer models, the self-attention mechanism is one of the main building blocks that strives to capture long-range dependencies, compared to the local convolutional-based design. However, the self-attention operation has quadratic complexity which proves to be a computational bottleneck, especially in volumetric medical imaging, where the inputs are 3D with numerous slices. In this paper, we propose a 3D medical image segmentation approach, named UNETR++, that offers both high-quality segmentation masks as well as efficiency in terms of parameters and compute cost. The core of our design is the introduction of a novel efficient paired attention (EPA) block that efficiently learns spatial and channel-wise discriminative features using a pair of inter-dependent branches based on spatial and channel attention. Our spatial attention formulation is efficient having linear complexity with respect to the input sequence length. To enable communication between spatial and channel-focused branches, we share the weights of query and key mapping functions that provide a complimentary benefit (paired attention), while also reducing the overall network parameters. Our extensive evaluations on three benchmarks, Synapse, BTCV and ACDC, reveal the effectiveness of the proposed contributions in terms of both efficiency and accuracy. On Synapse dataset, our UNETR++ sets a new state-of-the-art with a Dice Similarity Score of 87.2%, while being significantly efficient with a reduction of over 71% in terms of both parameters and FLOPs, compared to the best existing method in the literature. Code: https://github.com/Amshaker/unetr_plus_plus.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting microvessels in intravascular optical coherence tomography (IVOCT) images. A total of 8,403 IVOCT image frames from 85 lesions and 37 normal segments were analyzed. Manual annotation was done using a dedicated software (OCTOPUS) previously developed by our group. Data augmentation in the polar (r,{\theta}) domain was applied to raw IVOCT images to ensure that microvessels appear at all possible angles. Pre-processing methods included guidewire/shadow detection, lumen segmentation, pixel shifting, and noise reduction. DeepLab v3+ was used to segment microvessel candidates. A bounding box on each candidate was classified as either microvessel or non-microvessel using a shallow convolutional neural network. For better classification, we used data augmentation (i.e., angle rotation) on bounding boxes with a microvessel during network training. Data augmentation and pre-processing steps improved microvessel segmentation performance significantly, yielding a method with Dice of 0.71+/-0.10 and pixel-wise sensitivity/specificity of 87.7+/-6.6%/99.8+/-0.1%. The network for classifying microvessels from candidates performed exceptionally well, with sensitivity of 99.5+/-0.3%, specificity of 98.8+/-1.0%, and accuracy of 99.1+/-0.5%. The classification step eliminated the majority of residual false positives, and the Dice coefficient increased from 0.71 to 0.73. In addition, our method produced 698 image frames with microvessels present, compared to 730 from manual analysis, representing a 4.4% difference. When compared to the manual method, the automated method improved microvessel continuity, implying improved segmentation performance. The method will be useful for research purposes as well as potential future treatment planning.

大多数人工智能（AI）研究都集中在高收入国家，其中成像数据，IT基础设施和临床专业知识丰富。但是，在需要医学成像的有限资源环境中取得了较慢的进步。例如，在撒哈拉以南非洲，由于获得产前筛查的机会有限，围产期死亡率的率很高。在这些国家，可以实施AI模型，以帮助临床医生获得胎儿超声平面以诊断胎儿异常。到目前为止，已经提出了深度学习模型来识别标准的胎儿平面，但是没有证据表明它们能够概括获得高端超声设备和数据的中心。这项工作研究了不同的策略，以减少在高资源临床中心训练并转移到新的低资源中心的胎儿平面分类模型的域转移效果。为此，首先在丹麦的一个新中心对1,008例患者的新中心进行评估，接受了1,008名患者的新中心，后来对五个非洲中心（埃及，阿尔及利亚，乌干达，加纳和马拉维进行了相同的表现），首先在丹麦的一个新中心进行评估。 ）每个患者有25名。结果表明，转移学习方法可以是将小型非洲样本与发达国家现有的大规模数据库相结合的解决方案。特别是，该模型可以通过将召回率提高到0.92 \ pm 0.04 $，同时又可以维持高精度。该框架显示了在临床中心构建可概括的新AI模型的希望，该模型在具有挑战性和异质条件下获得的数据有限，并呼吁进行进一步的研究，以开发用于资源较少的国家 /地区的AI可用性的新解决方案。